MIAMI (AP) — Carlos Lee homered and drove in three runs and the Miami Marlins beat the Cincinnati Reds 6-4 on Saturday night.

Mark Buehrle (13-12) allowed four runs on seven hits over 7 2-3 innings to improve to 4-1 in his last six starts. Jose Reyes had three hits and also drove in a run for Miami.

Johnny Cueto (17-9) suffered his third straight loss and failed to last five innings for the second straight start. Cueto gave up six runs on nine hits in 4 1-3 innings, and hasn’t won since August 28 at Arizona. Ryan Ludwick homered for the Reds.

The Marlins chased Cueto with a three-run fifth, capped by a two-run homer by Lee, who hit a 3-1 pitch over the center field scoreboard that gave Miami a 6-2 lead. The homer followed Reyes’ double that scored Justin Ruggiano.

The Reds made it 6-4 on Ludwick’s two-run homer off Buehrle in the eighth. Buehrle was then replaced by Mike Dunn. Steve Cishek pitched a scoreless ninth for his 14th save in 18 opportunities.

Trailing 3-0, the Reds closed to 3-1 when Wilson Valdez singled in Ryan Hanigan in the third. Cincinnati picked up another run in the fourth after Jay Bruce tripled, then scored on a single by Scott Rolen to make it 3-2. It was Bruce’s first hit in 18 at-bats.

The Marlins jumped on Cueto for three runs in the first inning. After Ruggiano and Reyes hit consecutive one-out singles, Giancarlo Stanton drove in both with a triple. Lee then drove in Stanton with a sacrifice fly.

NOTES: Cincinnati rookie SS Zack Cozart, on the DL since Sept. 3 with a left oblique strain, took batting practice on Saturday. … The Reds bullpen hasn’t given up a run in 17 innings over the last five games.