GLENDALE, Ariz. (AP) — On an almost perfect Monday night for Alex Smith, the San Francisco 49ers flexed their NFC West dominance with a 24-3 flattening of the Arizona Cardinals.

Smith completed 18 of 19 passes for 232 yards and three touchdowns — two to Michael Crabtree and one to Randy Moss — to help San Francisco (6-2) open a two-game lead in the division and send Arizona (4-4) to its fourth straight lost.

Smith’s only incompletion was dropped by a wide-open receiver.

Smith was 14 of 15 for 146 yards and two touchdowns, both to Crabtree, as the 49ers built a 17-0 halftime lead.

Moss caught a 47-yard TD pass, dodging tacklers down the sideline on a play that seemed to turn back the clock to the receiver’s prime. With the catch, he tied Terrell Owens for fourth on the NFL career touchdown list with 156.

Smith, who tied a career high with the three touchdown passes, spread out his completions to 10 receivers. Crabtree led the way with five catches for 72 yards.

Arizona’s defense, supposed to be the team’s strength, missed tackle after tackle in an embarrassing nationally televised performance at home. The 24 points were the most allowed by the Cardinals this season.