SOUTH BEND, Ind. (AP) — Louisville found a different way to lose at Notre Dame.

After losing by 10 points or more in its three games in South Bend since 2007, including an overtime loss two years ago, the Cardinals squandered an eight-point lead in the final minute of regulation before losing 104-101 in five overtimes Saturday night.

Louisville coach Rick Pitino said it was a typical Notre Dame-Louisville game as it marked the sixth time in the last eight meetings that the game went beyond regulation.

But it had never gone more than two overtimes, going that long twice previously. The game turned out to be the longest game in Big East regular-season history.

“They just made incredible shots,” said Pitino, who didn’t take any questions from the media. “I can’t fault our defense. We were on them. … I’ve never seen shots like that and I’ve been coaching a long, long time.”

Chane Behanan, who led the Cardinals (19-5, 7-4) with a career-high 30 points and 15 rebounds, said Pitino’s message to the team afterward was that it was a good game.

“They were the better team,” Behanan said.

Both teams got help from players who usually don’t contribute as five players fouled out, two for Louisville and three for Notre Dame. Luke Hancock played 46 minutes and scored a career-high 22 points for the Cardinals.

“Everybody just has to be ready to get their number called in games like this,” Behanan said.

Notre Dame (19-5, 7-4) watched a video of great boxing knockouts on Friday knowing their game against Louisville would probably be bruising.

“I talked about it being a 15-rounder and taking punches and being put on the mat,” Irish coach Mike Brey said. “At the fourth or fifth timeout I said, ‘Has there ever been a 20-rounder?”

If so, it couldn’t have been any more thrilling. Afterward, even Pitino forgot how long the game was, referring to it as a four-overtime game.

The previous record for the conference in the regular season was a four-overtime game that happened 11 years ago to the day and also involved Notre Dame. The Irish beat Georgetown 116-11 in 4 OTs on Feb. 9, 2002.

Jack Cooley, who fouled out in regulation, said the Irish players scoffed at Brey when he talked about a 15-round boxing match.

“We’re like, 15 round matches, that doesn’t happen. And then we played five overtimes. So that’s how it went,” he said.

There was no knockout punch in Saturday night’s game — just some body blows.

Cameron Biedscheid scored on a layup with 1:19 left in the fifth overtime, and Eric Atkins and Pat Connaugton added free throws in the final 19 seconds.

Russ Smith had a chance to tie it at the end of the fifth overtime, but his 3-point attempt missed before Notre Dame students flooded the court to celebrate.

Both teams missed crucial free throws in the final minute. Atkins missed two with 37 seconds left and Montrezi Harrell did the same for Louisville with 24 seconds left. The lead changed hands 26 times and there were 16 ties.

“We missed some big free throws and we missed some shots and we never really hung our head,” Brey said

Pitino said the Cardinals made a few mental mistakes down the stretch when they had the lead by trying to force the issue.

“But sometimes when you’re a bad foul shooting team at times it’s not the worst thing in the world to get two points,” he said.

Jerian Grant, who fouled out with 1:57 left in the first overtime, led the Irish with 19 points. Garrick Sherman, playing because Cooley and Tom Knight fouled out, added 17 points on 7-of-10 shooting in overtime as the Notre Dame bench outscored Louisville’s 39-31. Connaughton added 16 points and 14 rebounds, Atkins added 14 points, and Cooley, who fouled out 6:54 left in regulation, finished with 11 points and 11 rebounds.

Luke Hancock added 22 points for Louisville, Smith had 21 points and 10 rebounds, and Gorgui Dieng had 17 points and 13 rebounds.

Both teams needed big shots to force the extra periods. In the fourth overtime, Atkins and Zach Auguste missed shots for the Irish, but Garrick Sherman tipped in the rebound to tie the score at 93 with 5 seconds left. Russ Smith had a last-second shot for the Cardinals but missed.

In the third overtime, Behanan scored inside with 16 seconds left to tie the score at 83. With 16 seconds left in the second overtime, Biedscheid hit a 3-pointer to force another period. Both teams missed chances to win in the first overtime. Behanan blocked a shot inside by Atkins with 15 seconds left, and Smith missed from 3-point range in the closing seconds for the Cardinals.

It didn’t look as if the Cardinals were going to need overtime when Behanan made a free throw with 51 seconds left in regulation to make it 56-48. But Grant led the Irish on a 12-4 comeback, hitting three straight 3-pointers and then tying it on a three-point play with 16 seconds left.

“I’ve never seen anything like that because I was about to strangle him for his play up until that point,” Brey said. “What he did there was amazing. Because people were going up the aisles. People were beginning to leave.”

The Cardinals had a chance to win, but they never got a shot off as Siva lost control of the ball under the basket in the closing seconds.

“They were a great team tonight and made a lot of big shots,” he said. “Give credit to the Grant kid. He’s a tremendous player and he held his team up.”