HOUSTON (AP) — Peyton Manning turned a colossal collapse by the Houston Texans into a stunning victory for the Indianapolis Colts.

The Colts scored 21 points in a late span of 2:10 — two touchdowns thanks to fumbles by Sage Rosenfels — then intercepted Rosenfels’ last-ditch comeback attempt for a 31-27 win Sunday.

Manning threw two touchdown passes, connecting with Reggie Wayne on a 5-yarder with 1:54 remaining for the decisive points. Linebacker Gary Brackett returned a fumble by quarterback Rosenfels 68 yards for a score in between Manning’s TD throws.

Rookie Tom Santi caught the other late score, a 7-yarder to bring the Colts (2-2) within 27-17 with 4:04 to go. It was his first NFL touchdown.

Backup Rosenfels, playing for the ill Matt Schaub, had the winless Texans (0-4) ahead by 17 points before losing two fumbles and throwing an interception. Texans fans had wanted to see Schaub replaced all season, and Rosenfels was nearly flawless for three quarters.