LAS VEGAS — Former Buffalo Bills quarterback J.P. Losman signed Tuesday with the Las Vegas franchise in the United Football League, which kicks off its first season in October.

Losman, a first-round draft pick in 2004 out of Tulane, is the most notable player to sign with the fledgling UFL so far.

‘‘The United Football League is providing me with the opportunity to play the sport I love at a high level and for that, I am extremely grateful,’’ said Losman. ‘‘I am excited to get back out onto the field and represent Las Vegas during the league’s first season.’’

Losman spent five seasons with the Bills after being selected 22nd overall in the draft. He played 42 games and passed for 6,211 yards with 33 touchdown passes and 34 interceptions.

In 2007, his 63.43 completion percentage was the fourth-single best in team history.