SANTA CLARA, Calif. (AP) — Joe Burrow threw three touchdown passes, Cincinnati intercepted Brock Purdy on back-to-back passes in the second half and the Bengals beat the San Francisco 49ers 31-17 on Sunday for their fourth win in five games.

After being hampered early in the season by a calf injury, Burrow came out of the bye week looking like his old self for the Bengals (4-3).

He managed to escape a sack attempt on a TD drive in the first quarter, had two long runs and was sharp all game throwing the ball against the 49ers (5-3), who lost their third straight game.

Burrow went 28 for 32 for 283 yards and ran for 43 more against a Niners defense that has uncharacteristically struggled in recent weeks.

Burrw helped Cincinnati take control of the game early in the fourth quarter after Logan Wilson intercepted a pass from Purdy. The Bengals struck on the next play when Burrow lofted a 17-yard TD pass to Ja’Marr Chase to make it 24-10.

Purdy had thrown an interception on the previous drive in the red zone to Germaine Pratt, giving him five interceptions in the past three games after having none in the first five.

Purdy, who played despite being in concussion protocol during the week, threw for 365 yards and had a TD pass to Christian McCaffrey on the drive after his back-to-back interceptions.

But Burrow responded with two long passes to Trenton Irwin and Chase and two first downs running to set up Joe Mixon’s 5-yard run with 2:54 left for the Bengals.

Purdy lost a fumble on a strip-sack to Trey Hendrickson to seal the loss for the 49ers, who have been held to 17 points or fewer in three straight games for the first time since Kyle Shanahan’s first season in 2017.

Burrow and the Bengals started fast as he connected on TD passes to Tyler Boyd and Andrei Iosivas on the first two drives of the game to take a 14-7 lead.

Cincinnati had chances to add to the lead but Evan McPherson missed a 50-yard field goal following a third-down sack and Irv Smith lost a fumble at the 49ers 5 late in the half to keep it 14-10.

RECORD WATCH

McCaffrey also scored on a 2-yard run in the first quarter, giving him at least one TD in 17 straight games, including the playoffs. That tied the NFL record set by Lenny Moore in 1963-64.

McCaffrey’s TD catch in the fourth quarter gave him at least one rushing and throwing in 14 games — one shy of Marshall Faulk’s NFL record.

INJURIES/INACTIVES

Bengals: Trey Hendrickson (left ankle) left briefly in the first half but was able to return.

49ers: LT Trent Williams missed his second straight game with a sprained ankle.

UP NEXT

Bengals: Host Buffalo on Sunday night.

49ers: Bye week; visit Jacksonville on Nov. 12.

Cincinnati	14	0	3	14	—	31
San Francisco	7	3	0	7	—	17

First Quarter

Cin–Boyd 7 pass from Burrow (McPherson kick), 8:11.

SF–McCaffrey 2 run (Moody kick), 3:19.

Cin–Iosivas 2 pass from Burrow (McPherson kick), :00.

Second Quarter

SF–FG Moody 36, 2:44.

Third Quarter

Cin–FG McPherson 56, 11:09.

Fourth Quarter

Cin–Chase 17 pass from Burrow (McPherson kick), 13:04.

SF–McCaffrey 4 pass from Purdy (Moody kick), 8:12.

Cin–Mixon 5 run (McPherson kick), 2:54.

A–71,655.

—————

	Cin	SF
First downs	29	24
Total Net Yards	400	460
Rushes-yards	27-134	23-113
Passing	266	347
Punt Returns	1-8	0-0
Kickoff Returns	2-53	1-16
Interceptions Ret.	2-25	0-0
Comp-Att-Int	28-32-0	22-31-2
Sacked-Yards Lost	3-17	2-18
Punts	3-46.667	3-50.333
Fumbles-Lost	2-1	1-1
Penalties-Yards	1-15	5-54
Time of Possession	31:23	28:37

—————

INDIVIDUAL STATISTICS

RUSHING–Cincinnati, Mixon 16-87, Burrow 6-43, Boyd 1-6, T.Williams 2-6, Chase 2-(minus 8). San Francisco, Purdy 6-57, McCaffrey 12-54, Mitchell 3-2, Juszczyk 2-0.

PASSING–Cincinnati, Burrow 28-32-0-283. San Francisco, Purdy 22-31-2-365.

RECEIVING–Cincinnati, Chase 10-100, Higgins 5-69, I.Smith 4-25, Boyd 3-40, Mixon 3-23, Irwin 2-24, Iosivas 1-2. San Francisco, Kittle 9-149, McCaffrey 6-64, Aiyuk 5-109, McCloud 2-43.

MISSED FIELD GOALS–Cincinnati, McPherson 50.