ATHENS (AP) — JD Sprague had 321 total yards and three touchdowns, A.J. Ouellette ran for a season-high 121 yards and two scores, and Ohio beat Ball State 48-31 on Tuesday night.

Sprague connected with Jordan Reid on two second-quarter touchdowns, of 7 and 60 yards, to give Ohio a 28-3 lead. Ball State scored on back-to-back possessions in the second half to get to 38-24, but Ohio had an answer each time — scoring on four straight drives.

Reid made four catches for 112 yards and two scores for Ohio (7-4, 4-3 Mid-American). Sprague was 15-of-22 passing for 275 yards and had 11 carries for 46 yards.

Ohio had 607 yards overall.

Riley Neal passed for 247 yards with two touchdowns and ran for 62 yards and a score for Ball State (3-8, 2-5). KeVonn Mabon caught 10 passes for 139 yards and one touchdown and Jordan Williams added 78 yards and a score.

Ball St. 3 7 14 7 = 31

Ohio 14 14 13 7 = 48

First Quarter

Ohio—Patterson 15 run (Yazdani kick), 10:21.

BSU—FG Hagee 45, 8:19.

Ohio—Ouellette 6 run (Yazdani kick), 2:10.

Second Quarter

Ohio—Reid 60 pass from Sprague (Yazdani kick), 14:51.

Ohio—Reid 7 pass from Sprague (Yazdani kick), 4:08.

BSU—Neal 1 run (Hagee kick), 1:49.

Third Quarter

Ohio—FG Yazdani 42, 10:50.

BSU—Mabon 20 pass from Neal (Hagee kick), 7:44.

Ohio—Ouellette 3 run (Yazdani kick), 4:48.

BSU—Williams 33 pass from Neal (Hagee kick), 3:12.

Ohio—FG Yazdani 41, 1:40.

Fourth Quarter

Ohio—S.Smith 7 pass from Sprague (Yazdani kick), 8:49.

BSU—Green 10 run (Hagee kick), 6:38.

A—16,148.

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BSU Ohio

First downs 18 30

Rushes-yards 30-174 56-332

Passing 247 275

Comp-Att-Int 16-34-0 15-22-0

Return Yards 12 (-1)

Punts-Avg. 4-41.0 3-39.3

Fumbles-Lost 2-1 1-0

Penalties-Yards 5-45 6-75

Time of Possession 22:16 37:44

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INDIVIDUAL STATISTICS

RUSHING—Ball St., Green 13-74, Neal 5-62, J.Gilbert 12-38. Ohio, Ouellette 22-121, D.Brown 12-82, Sprague 11-46, Patterson 4-44, Irons 5-32, Windham 2-7.

PASSING—Ball St., Neal 16-34-0-247. Ohio, Sprague 15-22-0-275.

RECEIVING—Ball St., Mabon 10-139, Williams 3-78, Brunner 2-22, D.Curry 1-8. Ohio, S.Smith 7-89, Reid 4-112, Cope 2-48, Ouellette 2-26.